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MCC 555
CAS No. 161600-01-7
MCC 555 ( Isaglitazone | Netoglitazone | RWJ 241947 )
产品货号. M12353 CAS No. 161600-01-7
MCC 555 (Isaglitazone;Netoglitazone;RWJ 241947) 是 PPARγ 的激活配体，EC50 为 8 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥518 | 有现货 |
|
| 10MG | ￥915 | 有现货 |
|
| 25MG | ￥1928 | 有现货 |
|
| 50MG | ￥3208 | 有现货 |
|
| 100MG | ￥4771 | 有现货 |
|
| 500MG | ￥10368 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MCC 555
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MCC 555 (Isaglitazone;Netoglitazone;RWJ 241947) 是 PPARγ 的激活配体，EC50 为 8 uM。
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产品描述MCC 555 (Isaglitazone;Netoglitazone;RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM, exhibts greater antidiabetic potency that other TZDs including BRL49653; profoundly suppresses growth of PC-3 prostate cancer xenografts with prominent apoptosis, as well as fibrosis, including inflammatory and giant cell reaction in the remaining tumor tissue.Diabetes Phase 2 Discontinued.
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体外实验——
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体内实验——
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同义词Isaglitazone | Netoglitazone | RWJ 241947
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通路Metabolic Enzyme/Protease
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靶点PPAR
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受体PPAR
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研究领域Metabolic Disease
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适应症Diabetes
化学信息
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CAS Number161600-01-7
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分子量381.421
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分子式C21H16FNO3S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 250 mg/mL (655.45 mM)
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SMILESO=C(N1)SC(CC2=CC=C3C=C(OCC4=CC=CC=C4F)C=CC3=C2)C1=O
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化学全称5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]-2,4-thiazolidinedione
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Reginato MJ, et al. J Biol Chem. 1998 Dec 4;273(49):32679-84.
2. Kumagai T, et al. Clin Cancer Res. 2004 Feb 15;10(4):1508-20.
3. Cekanova M, et al. Eur J Pharmacol. 2010 Jul 10;637(1-3):30-7.
产品手册
